What are the benefits of participating in a clinical research study?
There are a few benefits of taking part in a clinical research study. One benefit of this study is that,
if you qualify, you will have access to the investigational study medicine before it is widely
available—and at no cost to you. You can also play a more active role in your healthcare and receive more
frequent checkups and other medical care than you might normally. Finally, your participation could help
others who experience the same symptoms and challenges that you do, which can give you a sense of pride and
Who can participate?
The Grace Study is for adults 18 to 80 years of age with endogenous Cushing syndrome. There are additional
criteria for study participation that a study team member can go over with you.
What should I expect if I decide to participate in the Grace Study?
Before you can take part in the Grace Study, you will first need to attend a screening visit for initial
tests and assessments to see if you are eligible to participate.
After all necessary tests and assessments have been completed, you will enter the study and receive the
investigational study medicine for up to 26 weeks. The research staff will then perform another set of
tests to determine if you are eligible to continue study participation. Those who are eligible will have
a 50/50 chance of continuing to receive the investigational study medicine and will remain in the study
for an additional 12 weeks.
How long will study participation last?
Participation in the study could last up to 48 weeks. This includes six weeks for screening, up to 26
weeks for the first part of the study (which is the open-label phase), up to 12 weeks for the second part
(the randomized-withdrawal phase), and four weeks for the follow-up.
You may also be asked to return to the research site for extra visits at any time during the study if the
study doctor decides that extra assessments are needed for your safety.
Will everyone in the study receive the investigational study medicine?
Yes. If you qualify for and enroll in the study, you will receive relacorilant, the investigational
medicine, during the open-label phase for up to 26 weeks. Then, if you’re eligible to remain in the study,
there is a 50/50 chance that you will either continue to receive relacorilant or be assigned the placebo
Will I have to pay to participate?
No. Those who qualify will receive the investigational study medicine, study-related medical exams, and
study-related laboratory tests at no cost.
Can I leave the study if I change my mind?
Participation in any clinical research study is completely voluntary, and you may choose to leave the
study at any time for any reason. If you would like to leave the study, you should discuss this with your
study doctor, who will give you information about how to do this safely.
Learn more about the Grace Study